INT322821

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.06
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIA3) plasma membrane (GRIA3) protein complex (GRIA3)
GRIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 36 98.20 Very High Very High Very High
Migraine 276 97.16 Very High Very High Very High
Glutamate receptor 42 86.04 High High
central sensitization 6 74.12 Quite High
Glutamate 78 69.68 Quite High
Thalamus 6 65.52 Quite High
trigeminal ganglion 6 63.80 Quite High
Central nervous system 18 58.48 Quite High
Neurotransmitter 18 57.28 Quite High
antagonist 6 30.00 Quite Low
Disease Link Frequency Relevance Heat
Depression 36 98.20 Very High Very High Very High
Headache 270 97.16 Very High Very High Very High
Epilepsy 30 95.28 Very High Very High Very High
Stress 6 90.84 High High
Neuroblastoma 6 69.44 Quite High
Ganglion Cysts 6 63.80 Quite High
Shock 12 63.12 Quite High
Nociception 6 62.08 Quite High
Disease 30 28.64 Quite Low
Migraine With Aura 18 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, EMSA assays suggest that the -1952T>C polymorphism can affect the binding affinity of the GRIA3 promoter with transcription factor(s) and the variant T allele has a stronger binding strength compared with the C allele.
GRIA3 Binding (affinity) of
1) Confidence 0.47 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.29 Pain Relevance 0.20
These data suggest that the -1952T>C polymorphism can affect the binding affinity of the GRIA3 promoter with several transcription factor(s) and the variant T allele has a stronger binding strength compared with the C allele.
GRIA3 Binding (affinity) of
2) Confidence 0.47 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.13 Pain Relevance 0
Table 1 shows the oligo sets and genotyping procedures for the GRIA1 and GRIA3 associated SNPs.


GRIA3 Binding (associated) of
3) Confidence 0.37 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.09 Pain Relevance 0.09
Bioinformatics predictions showed that the C variant of GRIA3 gene could affect putative binding sites for transcription factors altering the consensus sequence.
GRIA3 Binding (binding) of
4) Confidence 0.37 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.26 Pain Relevance 0.18
Interestingly, both the GRIA1 and GRIA3 variants were specifically associated with MA suggesting a role of these genes in CSD, which is retained to be the path physiological mechanism-underlying aura.
GRIA3 Binding (associated) of associated with epilepsy and depression
5) Confidence 0.37 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.90 Pain Relevance 0.89
Therefore, the -1952T>C polymorphism may affect the GRIA3 promoter binding affinity with nuclear proteins and in turn the GRIA3 expression, which consequently modulates the individual's susceptibility to migraine.
GRIA3 Binding (affinity) of associated with migraine
6) Confidence 0.35 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.38 Pain Relevance 0.31

General Comments

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