INT322822

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.19
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIA3) plasma membrane (GRIA3) protein complex (GRIA3)
Anatomy Link Frequency
neocortex 1
GRIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 184 98.72 Very High Very High Very High
nMDA receptor 25 98.60 Very High Very High Very High
Neurotransmitter 14 88.84 High High
Glutamate receptor 33 87.52 High High
Glutamate 73 46.68 Quite Low
Pyramidal cell 8 27.80 Quite Low
long-term potentiation 14 24.96 Low Low
antagonist 5 10.72 Low Low
amygdala 58 5.00 Very Low Very Low Very Low
depression 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine With Aura 12 98.72 Very High Very High Very High
Headache 180 94.12 High High
Stress 13 90.84 High High
Autism 314 78.88 Quite High
Neuroblastoma 4 69.44 Quite High
Shock 8 63.12 Quite High
Drug Induced Neurotoxicity 2 43.60 Quite Low
Anxiety Disorder 52 5.00 Very Low Very Low Very Low
Cognitive Disorder 43 5.00 Very Low Very Low Very Low
Depression 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the -1952T>C polymorphism may affect the GRIA3 promoter binding affinity with nuclear proteins and in turn the GRIA3 expression, which consequently modulates the individual's susceptibility to migraine.
Spec (may) Regulation (affect) of GRIA3 associated with migraine
1) Confidence 0.61 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.38 Pain Relevance 0.30
These data suggest that the -1952T>C polymorphism can affect the binding affinity of the GRIA3 promoter with several transcription factor(s) and the variant T allele has a stronger binding strength compared with the C allele.
Regulation (affinity) of GRIA3
2) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.13 Pain Relevance 0
Moreover, EMSA assays suggest that the -1952T>C polymorphism can affect the binding affinity of the GRIA3 promoter with transcription factor(s) and the variant T allele has a stronger binding strength compared with the C allele.
Regulation (affinity) of GRIA3
3) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.29 Pain Relevance 0.20
These results indicate an involvement of GRIA1 and GRIA3 genes in the susceptibility to migraine with aura and encourage replication in other data sets.
Regulation (involvement) of GRIA3 associated with migraine
4) Confidence 0.27 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.32 Pain Relevance 0.36
As compared to control, the VPA-treated neocortex did not exhibit any alterations in the AMPA receptor subunits GluR1, GluR2, and GluR3 and the obligatory subunit of the NMDA receptor, NR1.
Neg (not) Regulation (alterations) of GluR3 in neocortex associated with nmda receptor
5) Confidence 0.09 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.08 Pain Relevance 0.25

General Comments

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