INT322824

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIA3) plasma membrane (GRIA3) protein complex (GRIA3)
GRIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 92 78.52 Quite High
Glutamate receptor 14 15.68 Low Low
antagonist 2 11.48 Low Low
Glutamate 26 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
trigeminal ganglion 2 5.00 Very Low Very Low Very Low
central sensitization 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 91.60 High High
Headache 90 78.52 Quite High
Neuroblastoma 2 70.20 Quite High
Shock 4 63.12 Quite High
Depression 12 5.00 Very Low Very Low Very Low
Epilepsy 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Migraine With Aura 6 5.00 Very Low Very Low Very Low
Ganglion Cysts 2 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the -1952T>C polymorphism can affect the binding affinity of the GRIA3 promoter with several transcription factor(s) and the variant T allele has a stronger binding strength compared with the C allele.
Regulation (affect) of Regulation (affinity) of GRIA3
1) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.13 Pain Relevance 0
Moreover, EMSA assays suggest that the -1952T>C polymorphism can affect the binding affinity of the GRIA3 promoter with transcription factor(s) and the variant T allele has a stronger binding strength compared with the C allele.
Regulation (affect) of Regulation (affinity) of GRIA3
2) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.29 Pain Relevance 0.20

General Comments

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