INT322846

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 7 Disease Relevance 1.06 Pain Relevance 0.08

cytosol (PDCD10) cell proliferation (OSM) extracellular space (OSM) extracellular region (OSM) Golgi apparatus (PDCD10) plasma membrane (PDCD10)

OSM (Homo sapiens) PDCD10 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 14 93.56 withdrawal 7 58.76 headache 7 38.12 Glutamate 14 5.00 imagery 14 5.00

Disease Link Frequency Relevance Heat Stroke 14 96.32 Congenital Anomalies 7 92.36 Apoptosis 63 85.36 Stress 7 76.24 Headache 7 38.12 Convulsion 7 37.28 Increased Venous Pressure Under Development 7 19.84 Metastasis 7 5.00 Aids-related Complex 7 5.00 Adhesions 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, we showed that all three CCM proteins (Krit1, OSM, and PDCD10) form a complex in the cell and that PDCD10 binds directly to OSM independently of the OSM-Krit1 interaction [28].

OSM Binding (binds) of PDCD10

1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0.48 Pain Relevance 0.03

However, it is not known which part of PDCD10 binds to PtdIns(3,4,5)P3 or OSM because there is currently no structural data available for PDCD10.

OSM Binding (binds) of PDCD10

2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0.31 Pain Relevance 0

These lysines are also important in PDCD10-OSM interaction.

OSM Binding (interaction) of PDCD10

3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

We therefore speculate that PDCD10-OSM and PDCD10-VEGFR2 interactions may be regulated by the availability of PtdIns(3,4,5)P3 generated by PI3K.

OSM Binding (interactions) of PDCD10

4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

These lysines are also important in PDCD10-OSM interaction.

OSM Binding (interaction) of PDCD10

5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

PDCD10 binds specifically to PtdIns(3,4,5)P3 and OSM.

OSM Binding (binds) of PDCD10

6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2909203 Disease Relevance 0.26 Pain Relevance 0.05

Recently, we demonstrated that PDCD10 interacts with the OSM-Krit1 complex by interacting with OSM [28].

OSM Binding (interacting) of PDCD10

7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

General Comments

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