INT322849

Context Info Confidence 0.16 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0 Pain Relevance 0

plasma membrane (PIK3CD, PDCD10) cytosol (PDCD10) cell differentiation (PIK3CD) signal transduction (PIK3CD) Golgi apparatus (PDCD10) cytoplasm (PDCD10)

Anatomy Link Frequency plasma 1 PIK3CD (Homo sapiens) PDCD10 (Homo sapiens)

Pain Link Frequency Relevance Heat withdrawal 4 17.56 Central nervous system 8 5.00 Glutamate 8 5.00 imagery 8 5.00 headache 4 5.00

Disease Link Frequency Relevance Heat Apoptosis 36 50.00 Adhesions 4 45.12 Stress 4 35.04 Stroke 8 5.00 Metastasis 4 5.00 Aids-related Complex 4 5.00 Congenital Anomalies 4 5.00 Headache 4 5.00 Increased Venous Pressure Under Development 4 5.00 Convulsion 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, a relationship between PDCD10 and PI3K would be evidence that CCM development may result from dysregulation in the PI3K pathway through PDCD10-PtdIns(3,4,5)P3 interaction.

PI3K Binding (interaction) of PDCD10

1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

We propose that CCM development may result from the dysregulation of the VEGF/PI3K signaling pathway through PDCD10- PtdIns(3,4,5)P3 interaction.

PI3K Binding (interaction) of PDCD10

2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

Thus, a relationship between PDCD10 and PI3K would be evidence that CCM development may result from dysregulation in the PI3K pathway through PDCD10-PtdIns(3,4,5)P3 interaction.

PI3K Binding (interaction) of PDCD10

3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

Finally, we demonstrated that using membrane-bound constitutively active PI3K (p110-CAAX), the wild-type (WT) PDCD10 co-localizes with the p110-CAAX mostly at the plasma membrane, while the mutants lacking Lys residues remain in the cytoplasm.

PI3K Binding (localizes) of PDCD10 in plasma

4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

General Comments

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