INT322850

Context Info Confidence 0.14 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 0

plasma membrane (KDR, PDCD10) cytoplasm (KDR, PDCD10) cytosol (PDCD10) extracellular region (KDR) Golgi apparatus (PDCD10) cytoplasmic membrane-bounded vesicle (KDR)

KDR (Homo sapiens) PDCD10 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 6 5.00 Glutamate 6 5.00 imagery 6 5.00 withdrawal 3 5.00 headache 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 27 50.00 Stroke 6 5.00 Metastasis 3 5.00 Aids-related Complex 3 5.00 Congenital Anomalies 3 5.00 Adhesions 3 5.00 Headache 3 5.00 Increased Venous Pressure Under Development 3 5.00 Stress 3 5.00 Convulsion 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was shown that PDCD10 interacts with VEGFR2 through its C-terminal region [66].

VEGFR2 Binding (interacts) of PDCD10

1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

Upon activation of VEGFR2 by VEGF, VEGFR2 binds to dimeric PDCD10, translocates to the membrane, and becomes activated.

VEGFR2 Binding (binds) of PDCD10

2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

It is possible that this colocalization is a result of PDCD10 and VEGFR2 interactions.

VEGFR2 Binding (interactions) of PDCD10

3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

General Comments

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