INT322852

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytosol (PDCD10) extracellular region (PIP) Golgi apparatus (PDCD10) plasma membrane (PDCD10) cytoplasm (PDCD10) biological_process (PIP)

PIP (Homo sapiens) PDCD10 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 2 5.00 Glutamate 2 5.00 imagery 2 5.00 withdrawal 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 9 50.00 Metastasis 1 23.16 Stroke 2 5.00 Aids-related Complex 1 5.00 Congenital Anomalies 1 5.00 Adhesions 1 5.00 Headache 1 5.00 Increased Venous Pressure Under Development 1 5.00 Stress 1 5.00 Convulsion 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, in PIP-Arrays, WT PDCD10 selectively binds PtdIns(3,4,5)P3 with high affinity, and phosphatidyl bisphosphate (phosphatidylinositol 3,4 bisphophate (PtdIns(3,4)P2), phosphatidylinositol 3,5 bisphophate (PtdIns(3,5)P2), and phosphatidylinositol 4,5 bisphophate (PtdIns(4,5)P2) with moderate but lower affinity (Fig. 4B–C).

PIP Binding (binds) of PDCD10

1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.