INT322870

Context Info Confidence 0.56 First Reported 2010 Last Reported 2010 Negated 0 Speculated 3 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.62 Pain Relevance 0.09

cytosol (PDCD10) Golgi apparatus (PDCD10) plasma membrane (PDCD10) cytoplasm (PDCD10)

PDCD10 (Homo sapiens)

Pain Link Frequency Relevance Heat withdrawal 3 71.40 headache 3 50.76 Central nervous system 6 33.68 Glutamate 6 5.00 imagery 6 5.00

Disease Link Frequency Relevance Heat Apoptosis 27 98.00 Stress 3 88.88 Headache 3 50.76 Convulsion 3 49.92 Stroke 6 48.36 Increased Venous Pressure Under Development 3 32.48 Metastasis 3 5.00 Aids-related Complex 3 5.00 Congenital Anomalies 3 5.00 Adhesions 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, PDCD10 may be regulated through phosphorylation and dephosphorylation, since it can be phosphorylated by STK25 and dephosphorylated by binding to the phosphatase domain of Fas-associated phosphatase-1 [27].

Spec (may) Regulation (regulated) of PDCD10

1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0.62 Pain Relevance 0.09

We therefore speculate that PDCD10-OSM and PDCD10-VEGFR2 interactions may be regulated by the availability of PtdIns(3,4,5)P3 generated by PI3K.

Spec (may) Regulation (regulated) of PDCD10-VEGFR2

2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

We therefore speculate that PDCD10-OSM and PDCD10-VEGFR2 interactions may be regulated by the availability of PtdIns(3,4,5)P3 generated by PI3K.

Spec (may) Regulation (regulated) of PDCD10

3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.