INT322888

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ihh) embryo development (Ihh) molecular_function (Ihh)
cellular_component (Ihh)
Anatomy Link Frequency
osteoblast 1
Ihh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 4 99.38 Very High Very High Very High
Osteoporosis 14 98.10 Very High Very High Very High
Stress 1 85.36 High High
Congenital Anomalies 18 5.00 Very Low Very Low Very Low
Intervertebral Disk Degeneration 8 5.00 Very Low Very Low Very Low
Calcification 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At fused stage, early markers for osteoblasts and chondrocytes (runx2, osterix, sox9 and bmp2) were upregulated whereas the osteoblast inhibitor (twist) and genes involved in chondrocyte hypertrophy (bmp4, mef2c, col10a, shh and ihh) were downregulated, results also supported by ISH.
Negative_regulation (downregulated) of ihh in osteoblast associated with hypertrophy and osteoporosis
1) Confidence 0.26 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.45 Pain Relevance 0

General Comments

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