INT322929

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 6.12
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHIT1) extracellular region (CHIT1) carbohydrate metabolic process (CHIT1)
lysosome (CHIT1)
Anatomy Link Frequency
lung 8
CHIT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 84.92 Quite High
cytokine 8 82.16 Quite High
antagonist 4 30.88 Quite Low
Central nervous system 20 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 4 100.00 Very High Very High Very High
Sarcoidosis 4 99.90 Very High Very High Very High
Pulmonary Disease 4 99.48 Very High Very High Very High
Gauchers Disease 272 98.60 Very High Very High Very High
Interstitial Lung Diseases 4 97.76 Very High Very High Very High
Osteoporosis 8 92.24 High High
Hypercalcemia 4 91.04 High High
INFLAMMATION 24 84.92 Quite High
Disease 60 74.68 Quite High
Autosomal Disorder 4 42.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While chitotriosidase is one of the established biomarkers for GD, it has been recently used as an indicator in alveolar lung diseases, such as sarcoidosis and miliary tuberculosis.93,94 Chitotriosidase levels are shown to be significantly higher in patients with idiopathic interstitial lung disease.95
Positive_regulation (tuberculosis.93,94) of Gene_expression (levels) of Chitotriosidase in lung associated with mycobacterial infection, interstitial lung diseases, pulmonary disease, sarcoidosis and gauchers disease
1) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 1.54 Pain Relevance 0.21
While chitotriosidase is one of the established biomarkers for GD, it has been recently used as an indicator in alveolar lung diseases, such as sarcoidosis and miliary tuberculosis.93,94 Chitotriosidase levels are shown to be significantly higher in patients with idiopathic interstitial lung disease.95
Positive_regulation (shown) of Gene_expression (levels) of Chitotriosidase in lung associated with mycobacterial infection, interstitial lung diseases, pulmonary disease, sarcoidosis and gauchers disease
2) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 1.53 Pain Relevance 0.21
While chitotriosidase is one of the established biomarkers for GD, it has been recently used as an indicator in alveolar lung diseases, such as sarcoidosis and miliary tuberculosis.93,94 Chitotriosidase levels are shown to be significantly higher in patients with idiopathic interstitial lung disease.95
Positive_regulation (miliary) of Gene_expression (levels) of Chitotriosidase in lung associated with mycobacterial infection, interstitial lung diseases, pulmonary disease, sarcoidosis and gauchers disease
3) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 1.54 Pain Relevance 0.21
While chitotriosidase is one of the established biomarkers for GD, it has been recently used as an indicator in alveolar lung diseases, such as sarcoidosis and miliary tuberculosis.93,94 Chitotriosidase levels are shown to be significantly higher in patients with idiopathic interstitial lung disease.95
Positive_regulation (While) of Gene_expression (one) of chitotriosidase in lung associated with mycobacterial infection, interstitial lung diseases, pulmonary disease, sarcoidosis and gauchers disease
4) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 1.51 Pain Relevance 0.20

General Comments

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