INT322930

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GBA) hydrolase activity, acting on glycosyl bonds (GBA) cell death (GBA)
carbohydrate metabolic process (GBA) lipid metabolic process (GBA)
GBA (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 5 46.88 Quite Low
Pain 2 21.60 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 95.72 Very High Very High Very High
Gauchers Disease 68 77.44 Quite High
Splenomegaly 2 40.96 Quite Low
Hypersplenism 1 38.40 Quite Low
Anaemia 1 36.40 Quite Low
Thrombocytopenia 1 35.52 Quite Low
Pancytopenia 1 34.08 Quite Low
Spontaneous Fractures 1 23.92 Low Low
Pain 1 21.60 Low Low
Necrosis 1 20.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The majority of GBA mutations lead to the synthesis of GC with decreased catalytic function and/or stability.6 While it is assumed that disease severity depends on residual GC activity, this has been difficult to prove for most GBA mutations.7
Regulation (majority) of Gene_expression (mutations) of GBA associated with disease
1) Confidence 0.39 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0.26 Pain Relevance 0

General Comments

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