INT322965

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.51
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8, Cxcr2) intracellular (IL8, Cxcr2) extracellular space (IL8)
extracellular region (IL8) plasma membrane (Cxcr2) signal transducer activity (Cxcr2)
Anatomy Link Frequency
endothelial cells 2
neutrophil 2
IL8 (Homo sapiens)
Cxcr2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 200 64.20 Quite High
Inflammation 84 63.60 Quite High
Inflammatory response 16 32.40 Quite Low
cytokine 48 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 100 63.60 Quite High
Injury 28 61.20 Quite High
Viral Infection 4 60.48 Quite High
Disease 28 44.16 Quite Low
Bacterial Infection 8 26.00 Quite Low
Sepsis 4 22.00 Low Low
Infection 40 5.00 Very Low Very Low Very Low
Apoptosis 20 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 16 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCL8 mediates its function by binding to CXCR2 receptor on neutrophils and to GAGs on endothelial cells.
CXCL8 Binding (binding) of CXCR2 in endothelial cells
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0
On the basis of our data, we propose that dynamic equilibrium between CXCL8 monomers and dimers and their differential binding to CXCR2 and GAGs mediates and regulates in vivo neutrophil recruitment.
CXCL8 Binding (binding) of CXCR2 in neutrophil
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2909905 Disease Relevance 0.16 Pain Relevance 0.06
On the basis of our data, we propose that dynamic equilibrium between CXCL8 monomers and dimers and their differential binding to CXCR2 and GAGs mediates and regulates in vivo neutrophil recruitment.
CXCL8 Binding (binding) of CXCR2 in neutrophil
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2909905 Disease Relevance 0.16 Pain Relevance 0.06
CXCL8 mediates its function by binding to CXCR2 receptor on neutrophils and glycosaminoglycans (GAGs) on endothelial cells.
CXCL8 Binding (binding) of CXCR2 in endothelial cells
4) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2909905 Disease Relevance 0.19 Pain Relevance 0.06

General Comments

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