INT322977

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nox4) oxidoreductase activity (Nox4) aging (Nox4)
cell morphogenesis (Nox4) endoplasmic reticulum (Nox4) plasma membrane (Nox4)
Anatomy Link Frequency
endothelial cells 2
Nox4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bioavailability 12 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Restless leg syndrome 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 3 99.00 Very High Very High Very High
Diabetes Mellitus 141 98.60 Very High Very High Very High
Adhesions 9 97.68 Very High Very High Very High
Stress 9 97.36 Very High Very High Very High
Parkinson's Disease 3 92.52 High High
Hyperglycemia 39 86.56 High High
Obesity 3 86.28 High High
Pressure And Volume Under Development 3 64.44 Quite High
Hypertension 9 55.40 Quite High
Coronary Artery Disease 12 15.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subcellular localization of NOX4 is cell type dependent with NOX4 being localized to the mitochondria in cardiomyocytes, in the nucleus of endothelial cells, and at focal adhesions within vascular smooth muscle [42], [43], [44], [48], [49].
Localization (localization) of NOX4 in endothelial cells associated with adhesions
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 1.14 Pain Relevance 0
Localization of NOX4 to the endothelial nuclei could significantly accelerate oxidant stress induce DNA modifications [49].
Localization (Localization) of NOX4 associated with stress
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.89 Pain Relevance 0
Subcellular localization of NOX4 is cell type dependent with NOX4 being localized to the mitochondria in cardiomyocytes, in the nucleus of endothelial cells, and at focal adhesions within vascular smooth muscle [42], [43], [44], [48], [49].
Localization (localized) of NOX4 in endothelial cells associated with adhesions
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 1.14 Pain Relevance 0

General Comments

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