INT32300

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Context Info
Confidence 0.36
First Reported 1980
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.51
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ptgfr) plasma membrane (Ptgfr) cytoplasm (Ptgfr)
signal transducer activity (Ptgfr)
Anatomy Link Frequency
outflow 1
Ptgfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 16 98.56 Very High Very High Very High
Paracetamol 3 96.72 Very High Very High Very High
agonist 11 90.16 High High
Analgesic 1 75.00 Quite High
Dismenorea 1 42.48 Quite Low
Glutamate 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Onset of action 3 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 90 98.20 Very High Very High Very High
Heart Rate Under Development 5 96.40 Very High Very High Very High
Hypotension 16 95.28 Very High Very High Very High
Cv Unclassified Under Development 2 92.20 High High
Glaucoma 80 80.24 Quite High
Conjunctivitis 3 58.68 Quite High
Pigment Disorder 1 12.00 Low Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Blindness 8 5.00 Very Low Very Low Very Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An interference of the formation of PGF2 alpha with the cardiovascular effects of clonidine cannot be completely excluded since paracetamol pretreatment potentiated the bradycardic effect of clonidine.
PGF2 alpha Binding (formation) of associated with paracetamol and clonidine
1) Confidence 0.36 Published 1980 Journal Prostaglandins Section Abstract Doc Link 7413993 Disease Relevance 0.64 Pain Relevance 1.27
Association (specific and non-specific binding) of PGE2 and PGF2 alpha with MPM at pH 7 was found to require Ca2+ (half-maximal concentration approximately 0.7 mmol/l).
PGF2 Binding (binding) of
2) Confidence 0.25 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 2944978 Disease Relevance 0 Pain Relevance 0
Following absorption into the eye, the free acid form of travaprost interacts with the endogenous FP prostanoid receptor, to enhance aqueous humor outflow and lower intraocular pressure (IOP).
FP prostanoid receptor Binding (interacts) of in outflow associated with ocular hypertension
3) Confidence 0.03 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 0.87 Pain Relevance 0.09

General Comments

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