INT32301

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Context Info
Confidence 0.38
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.07
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
plasma 2
pore 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 27 94.52 High High
Glutamate 8 92.48 High High
fibrosis 9 92.44 High High
Kinase C 5 77.96 Quite High
agonist 14 39.24 Quite Low
Dismenorea 1 38.92 Quite Low
Neurotransmitter 12 37.80 Quite Low
Action potential 14 19.20 Low Low
Central nervous system 23 11.56 Low Low
addiction 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 1 92.44 High High
Myocardial Infarction 27 87.68 High High
Hypertrophy 80 86.96 High High
Cystic Fibrosis 8 55.04 Quite High
Hypertension 2 51.44 Quite High
Dilated Cardiomyopathy 1 35.72 Quite Low
Disease 1 20.80 Low Low
Ganglion Cysts 17 10.96 Low Low
Depression 12 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study has been focused on the mechanisms that modify Ca2+ transient generation, which depends directly on the following factors:
Regulation (modify) of Ca2 Binding (generation) of
1) Confidence 0.38 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 1.01 Pain Relevance 0.05
How steeply does the coupling depend on depolarization, channel gating, and Ca2+ influx?
Regulation (depend) of Ca2 Binding (coupling) of
2) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0
Effect of prostaglandins E2 and F2 alpha on membrane calcium binding, Ca2+/Mg2+-ATPase activity and membrane fluidity in rat myometrial plasma membranes.
Regulation (Effect) of Ca2 Binding (binding) of in plasma
3) Confidence 0.15 Published 1986 Journal J. Endocrinol. Section Title Doc Link 2944978 Disease Relevance 0 Pain Relevance 0
50%, probably by affecting Ca2+/calmodulin binding (Hayashi et al., 1999; Komeima et al., 2000).
Regulation (affecting) of Ca2 Binding (binding) of
4) Confidence 0.04 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.17
Mutagenesis of residues within Orai1, predicted to be important for Ca2+ binding within the pore of the channel, also markedly attenuated SOCE and ICRAC [27].
Regulation (important) of Ca2 Binding (binding) of in pore
5) Confidence 0.04 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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