INT323018

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 6.86
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PTX3)
PTX3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 93 98.68 Very High Very High Very High
Inflammation 21 88.32 High High
Inflammatory mediators 4 87.92 High High
depression 4 49.60 Quite Low
ischemia 6 5.00 Very Low Very Low Very Low
Inflammatory marker 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 6 99.88 Very High Very High Very High
Diabetes Mellitus 6 99.50 Very High Very High Very High
Hypertension 6 99.12 Very High Very High Very High
Heart Rate Under Development 44 98.86 Very High Very High Very High
Cv General 3 Under Development 81 98.68 Very High Very High Very High
Stable Angina Pectoris 12 98.04 Very High Very High Very High
Acute Coronary Syndrome 84 96.72 Very High Very High Very High
Nicotine Addiction 2 95.64 Very High Very High Very High
Abdominal Obesity 28 95.16 Very High Very High Very High
Myocardial Infarction 135 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, the serum PTX3 concentration was significantly correlated to Troponin T and the degree of Killip class, in CHF, among the parameters determining the GRACE risk scores, and the degree of Killip class was independently associated with an incremental change in the serum PTX3 level.
Regulation (change) of PTX3 associated with heart rate under development
1) Confidence 0.27 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.44 Pain Relevance 0.43
The Killip class that reflects CHF is an independent factor associated with an incremental change in the serum PTX3 level.
Regulation (change) of PTX3 associated with heart rate under development
2) Confidence 0.27 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 0.81 Pain Relevance 0.19
The aim of this study was to prove whether the value of PTX3 could be a prognostic marker, with the use of the GRACE risk assessment tool, in ACS patients.


Regulation (value) of PTX3 associated with acute coronary syndrome
3) Confidence 0.27 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.40 Pain Relevance 0.24
A study by Inoue et al.26) compared 52 patients with stable angina pectoris (SAP) to 16 patients with UAP and reported that PTX3 was not associated with coronary risk factors including hypertension, diabetes mellitus and hyperlipidemia; the value of PTX3 was significantly higher in the UAP than in the SAP group.
Regulation (value) of PTX3 associated with stable angina pectoris, angina, diabetes mellitus, hypertension and hyperlipidemia
4) Confidence 0.27 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.84 Pain Relevance 0.73
Among these patients, 4 (10%) were on statins; nonetheless, the use of statins did not appear to affect levels of PTX3 (2.35±1.89 vs. 2.32±2.45, p=0.98), CRP (1.85±1.77 vs. 1.09±1.22, p<0.13) or serum lipids and it was not associated with abdominal obesity.


Spec (appear) Regulation (affect) of PTX3 associated with abdominal obesity
5) Confidence 0.23 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.38 Pain Relevance 0

General Comments

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