INT323146

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.54

nucleoplasm (PRKCA, MAPK1) mitochondrion (PRKCA, MAPK1) cytoplasm (PRKCA, MAPK1) cytosol (PRKCA, MAPK1) signal transduction (PRKCA, MAPK1) nucleus (PRKCA, MAPK1)

PRKCA (Homo sapiens) MAPK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 12 100.00 Calcium channel 14 92.64 agonist 38 91.52 GABAergic 6 11.76 tetrodotoxin 8 5.00 imagery 7 5.00 Serotonin 4 5.00 gABA 3 5.00 Neurotransmitter 3 5.00 Glutamate 3 5.00

Disease Link Frequency Relevance Heat Hot Flashes 10 5.00 Targeted Disruption 5 5.00 Cancer 5 5.00 Breast Cancer 4 5.00 Rheumatoid Arthritis 4 5.00 Infection 3 5.00 Toxicity 2 5.00 Reprotox - General 3 2 5.00 Endometriosis (extended) 2 5.00 Uterine Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PKC stimulates the ERK/MAPK and AKT pathway by phosphorylating and activating Raf-1 and AKT [85].

PKC Positive_regulation (stimulates) of ERK associated with kinase c

1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.54

General Comments

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