INT323152

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.29
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (DBT, ESR1) nucleoplasm (ESR1) mitochondrion (DBT)
small molecule metabolic process (DBT) enzyme binding (ESR1) DNA binding (ESR1)
DBT (Homo sapiens)
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 40 91.76 High High
GABA receptor 1 67.96 Quite High
Opioid 1 67.08 Quite High
GABAergic 6 65.72 Quite High
Dopamine 26 65.12 Quite High
Kinase C 12 62.68 Quite High
Potency 2 57.44 Quite High
Morphine 2 48.84 Quite Low
Neurotransmitter 25 5.00 Very Low Very Low Very Low
depression 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 2 97.32 Very High Very High Very High
Cancer 23 89.56 High High
Heart Disease 4 82.04 Quite High
Osteoporosis 2 81.12 Quite High
Hot Flashes 14 80.56 Quite High
Endometriosis (extended) 8 79.72 Quite High
Breast Cancer 4 78.28 Quite High
Targeted Disruption 7 72.56 Quite High
Disease 32 61.60 Quite High
Mental Disorders 6 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike E2, which binds to both ER subtypes with relatively equal affinity, some phytoestrogens bind with higher affinity to ER?
E2 Binding (bind) of ER
1) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.57 Pain Relevance 0.03
Unlike E2, which binds to both ER subtypes with relatively equal affinity, some phytoestrogens bind with higher affinity to ER?
E2 Binding (binds) of ER
2) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.57 Pain Relevance 0
Second, the stimulatory effects of E2 on [Ca2+]i oscillations were blocked by tamoxifen (data not shown), which competes with E2 for binding to ER?
E2 Binding (binding) of ER
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0.15 Pain Relevance 0.24

General Comments

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