INT32324

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1986
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 6.43
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Eda) cell differentiation (Eda) extracellular region (Eda)
plasma membrane (Eda)
Anatomy Link Frequency
macrophages 3
striatum 2
palate 2
synovial fluids 1
adult brain 1
Eda (Mus musculus)
Pain Link Frequency Relevance Heat
Snapping jaw 11 99.76 Very High Very High Very High
Eae 17 99.70 Very High Very High Very High
COX2 7 98.92 Very High Very High Very High
narcan 3 98.32 Very High Very High Very High
IPN 4 95.80 Very High Very High Very High
Arthritis 4 95.80 Very High Very High Very High
midbrain 1 93.64 High High
opioid receptor 7 93.12 High High
amygdala 1 93.08 High High
Inflammation 51 92.80 High High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 11 99.76 Very High Very High Very High
Repression 53 99.04 Very High Very High Very High
Cancer 8 98.72 Very High Very High Very High
Necrosis 3 98.48 Very High Very High Very High
Reprotox - General 3 2 97.76 Very High Very High Very High
Varicocele 1 97.00 Very High Very High Very High
Injury 11 96.04 Very High Very High Very High
Adhesions 8 95.88 Very High Very High Very High
Inflammatory Pain 4 95.80 Very High Very High Very High
Arthritis 4 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glomerular volume and expression of PCNA, Thy1, and ED1/CD68 were analyzed in kidney sections.
Spec (analyzed) Gene_expression (expression) of ED1 in kidney
1) Confidence 0.75 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18385270 Disease Relevance 0.49 Pain Relevance 0.60
Eda (encoding the EDA ligand) is expressed in the epithelium of the palate (SP, data not shown and [38]), and we previously have shown increased variability and occurrence of anomalies in the ruga pattern of EdaTabby (EdaTa) null mutant mice [3].
Gene_expression (expressed) of Eda in palate
2) Confidence 0.63 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
While the Wnt and EDA-EDAR pathways do not seem to be involved, the FGF and BMP pathways should be investigated in the future.
Gene_expression (pathways) of EDA
3) Confidence 0.55 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0.07 Pain Relevance 0
A significant genetic correlation between adaptation to the novel environment (locomotor activity at 30 min subtracted from locomotor activity at 5 min) and beta-ED levels in the septum was observed.
Gene_expression (levels) of beta-ED associated with eae
4) Confidence 0.53 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9678655 Disease Relevance 0.65 Pain Relevance 0.51
Eda (encoding the EDA ligand) is expressed in the epithelium of the palate (SP, data not shown and [38]), and we previously have shown increased variability and occurrence of anomalies in the ruga pattern of EdaTabby (EdaTa) null mutant mice [3].
Gene_expression (expressed) of EDA in palate
5) Confidence 0.49 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
The Ctla4, Eda, and Mrgpre genes are in the signaling category but are not found in the OKDB.
Neg (not) Gene_expression (found) of Eda
6) Confidence 0.43 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.15 Pain Relevance 0.04
The Eda gene encodes the protein ectodysplasin A, a tumor necrosis factor family member with several isoforms, one of which is a transmembrane protein [52].
Gene_expression (encodes) of Eda associated with necrosis and cancer
7) Confidence 0.43 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.44 Pain Relevance 0.03
Three of the genes that we have included in Table 2 were not found in the OKdb: Mrgpre, Ctla4 and Eda.
Neg (not) Gene_expression (found) of Eda
8) Confidence 0.37 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.10 Pain Relevance 0
The expression of OX6 or ED1 immunoreactivity in the synovial lining cells might be involved in the initial immune responses in this arthritis model because the synovial membranes are exposed to the synovial fluids which have been believed to contain antigenic substances.
Gene_expression (expression) of ED1 in synovial fluids associated with arthritis
9) Confidence 0.35 Published 1998 Journal Arch. Histol. Cytol. Section Abstract Doc Link 9990429 Disease Relevance 0.70 Pain Relevance 0.52
Some of these COX2-IR cells were identified as macrophages because they coexpressed ED1.
Gene_expression (coexpressed) of ED1 in macrophages associated with cox2
10) Confidence 0.10 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 11918652 Disease Relevance 0.47 Pain Relevance 0.64
Furthermore, formalin-induced region-specific increase in activated microglia was confirmed by ED1 and endothelial monocytes activating polypeptide II (EMAP-II) expression.
Gene_expression (expression) of ED1 in monocytes
11) Confidence 0.10 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15885314 Disease Relevance 0.40 Pain Relevance 0.53
The density of ED1, GFAP, and NeuN immunoreactive cells in the striatum was evaluated by counting of immunoreactive cells and expressed as the number of cells/mm2.
Gene_expression (expressed) of ED1 in striatum
12) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430697 Disease Relevance 0.08 Pain Relevance 0.05
More than 80% EP1- and about 30% EP4-IR cells were identified as infiltrating macrophages since they coexpressed ED1.
Gene_expression (coexpressed) of ED1 in macrophages
13) Confidence 0.10 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552899 Disease Relevance 0.30 Pain Relevance 0.53
Only 3% EP2- and 6% EP3-IR cells coexpressed ED1.
Gene_expression (coexpressed) of ED1
14) Confidence 0.10 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552899 Disease Relevance 0.31 Pain Relevance 0.53
Detailed analysis, at a single time point of 1 d post-QUIN injection, showed excitotoxin-injected striatum to exhibit marked increases in microgliosis (ED1 marker), astrogliosis (GFAP marker) and VEGF expression, compared with PBS injection.
Gene_expression (expression) of ED1 in striatum
15) Confidence 0.08 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2430697 Disease Relevance 0.26 Pain Relevance 0.22
These cells expressed mostly ED1 (Figure 2C) but rarely MHC class II (OX6; arrow in Figure 2D).
Gene_expression (expressed) of ED1
16) Confidence 0.07 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.18 Pain Relevance 0.09
These cells expressed the macrophage markers, ED1 (data not shown) and ED3 (Figure 4A).
Gene_expression (expressed) of ED1 in macrophage
17) Confidence 0.07 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
The appearance of ED1-reactive cells and temporal vascularization may play crucial roles in the upper and lower articular cavity formation, respectively.
Gene_expression (appearance) of ED1 in cavity
18) Confidence 0.06 Published 2005 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 16110516 Disease Relevance 0.44 Pain Relevance 0.27
Beta-endorphin (beta-ED) levels were evaluated in blood and seminal plasma of men with infertility due to varicocele, obstructive and nonobstructive azoospermia, and idiopathic oligoasthenospermia.
Gene_expression (levels) of beta-ED in blood associated with male infertility, varicocele and reprotox - general 3
19) Confidence 0.03 Published 1986 Journal Arch. Androl. Section Abstract Doc Link 2946270 Disease Relevance 0.42 Pain Relevance 0.08
Both Bax founder mice and mice expressing the transgene for the reverse tetracycline transactivator (rtTA) under the control of the rat nestin intron II enhancer/promoter [34] were amplified in a C57BL/6J (Charles River, Lyon, France) genetic background.
Gene_expression (expressing) of rtTA
20) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox