INT323262

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.32
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
heart 2
Pde5a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 1 87.60 High High
Angina 1 33.44 Quite Low
potassium channel 4 28.28 Quite Low
tolerance 1 9.24 Low Low
Tetrahydrobiopterin 21 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 2 99.80 Very High Very High Very High
Hypertension 45 96.28 Very High Very High Very High
Myocardial Infarction 2 95.32 Very High Very High Very High
Thrombosis 1 89.80 High High
Increased Venous Pressure Under Development 14 89.16 High High
Coronary Artery Disease 1 87.60 High High
Disease 2 80.96 Quite High
Acute Decompensated Heart Failure (ADHF) 1 79.36 Quite High
Cardiovascular Disease 9 57.68 Quite High
Diabetes Mellitus 7 53.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific PDE-5 inhibitors are currently prescribed for erectile dysfunction but, in the future, their therapeutic indications may also include pulmonary hypertension, heart failure, and essential hypertension [22].


Negative_regulation (prescribed) of Negative_regulation (inhibitors) of PDE-5 in heart associated with reprotox - general 2, hypertension and myocardial infarction
1) Confidence 0.03 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 1.32 Pain Relevance 0.04

General Comments

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