INT32327

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Context Info
Confidence 0.45
First Reported 1984
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (POMC, PRL) small molecule metabolic process (POMC) cell-cell signaling (POMC)
cytoplasm (POMC) cell proliferation (PRL) cytosol (PRL)
Anatomy Link Frequency
follicle 2
POMC (Homo sapiens)
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 2 100.00 Very High Very High Very High
Morphine 3 99.88 Very High Very High Very High
Endogenous opioid 1 99.20 Very High Very High Very High
antagonist 1 98.48 Very High Very High Very High
Somatostatin 3 97.32 Very High Very High Very High
cytokine 2 93.96 High High
analgesia 1 92.32 High High
Nerve growth factor 1 89.36 High High
Enkephalin 1 86.64 High High
Clonidine 1 84.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The beta-endorphin-induced secretion of growth hormone but not of prolactin is inhibited by an endogenous opioid antagonist.
beta-endorphin Neg (not) Positive_regulation (induced) of Localization (secretion) of prolactin associated with antagonist and endogenous opioid
1) Confidence 0.45 Published 1986 Journal Eur. J. Pharmacol. Section Title Doc Link 2946593 Disease Relevance 0 Pain Relevance 0.24
It inhibited both morphine- and beta-endorphin-induced prolactin release, while it was ineffective on the release of growth hormone.
beta-endorphin-induced Positive_regulation (induced) of Localization (release) of prolactin associated with morphine
2) Confidence 0.36 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6329787 Disease Relevance 0 Pain Relevance 0.27
The co-existence of pituitary hormone and neuropeptide secretion [growth hormone (GH), prolactin (PRL), adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH), triiodothyronine (T3), somatostatin, oxytocin (OT), follicle stimulating hormone (FSH), luteinizing hormone (LH), arginine vasopressin (AVP), growth hormone releasing hormone (GHRH), corticotropin releasing hormone (CRH), nerve growth factor (NGF), vasoactive intestinal peptide (VIP), pro-enkephalin (pro-enk), and beta-endorphin (beta-end)], as well as production of a number of interleukins and growth factors and expression of receptors for all, by RE cells is an unique molecular biological phenomenon.
adrenocorticotropic hormone Positive_regulation (co-existence) of Localization (secretion) of prolactin in follicle associated with nerve growth factor, somatostatin, neuropeptide and enkephalin
3) Confidence 0.33 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928121 Disease Relevance 0 Pain Relevance 0.28
Glucagon (1 microM), ACTH (2.5 microM), human and bovine growth hormone (4.6 and 2.1 microM), prolactin (0.27 microM), corticosterone (0.4 microM), androstanolone (10(-2) microM), estradiol and estrone (10 microM), triiodothyronine and thyroxine (1 microM) enhanced significantly the glucose-induced insulin secretion.
ACTH Positive_regulation (enhanced) of Localization (secretion) of prolactin
4) Confidence 0.01 Published 1998 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 9827019 Disease Relevance 0 Pain Relevance 0.20

General Comments

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