INT323278

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.93
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dhfr) mRNA binding (Dhfr)
Dhfr (Rattus norvegicus)
Igkv1-131 (Mus musculus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 42 99.60 Very High Very High Very High
Bioavailability 8 66.96 Quite High
potassium channel 8 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
cOX1 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
TRP channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 28 87.36 High High
Nicotine Addiction 2 67.60 Quite High
Hypertension 90 65.20 Quite High
Diabetes Mellitus 14 64.08 Quite High
Hyperlipidemia 4 63.28 Quite High
Coronary Heart Disease 4 61.28 Quite High
Stress 8 58.12 Quite High
Atherosclerotic Plaque 2 43.40 Quite Low
Cardiovascular Disease 18 29.60 Quite Low
Atherosclerosis 2 9.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An alternative pathway for BH4 synthesis, the “salvage pathway,” involves the formation of sepiapterin and its subsequent reduction in dihydrobiopterin (BH2), which is further reduced by dihydrofolate reductase (DHFR) to form BH4.
dihydrofolate reductase Negative_regulation (reduced) of Negative_regulation (reduction) of BH2 associated with tetrahydrobiopterin
1) Confidence 0.02 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.46 Pain Relevance 0.51
An alternative pathway for BH4 synthesis, the “salvage pathway,” involves the formation of sepiapterin and its subsequent reduction in dihydrobiopterin (BH2), which is further reduced by dihydrofolate reductase (DHFR) to form BH4.
DHFR Negative_regulation (reduced) of Negative_regulation (reduction) of BH2 associated with tetrahydrobiopterin
2) Confidence 0.02 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.47 Pain Relevance 0.51

General Comments

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