INT323346

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyrp1) signal transduction (Gpr35) oxidoreductase activity (Tyrp1)
plasma membrane (Gpr35) signal transducer activity (Gpr35)
Tyrp1 (Mus musculus)
Gpr35 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor antagonist 1 98.64 Very High Very High Very High
depression 7 94.96 High High
Serotonin 15 77.96 Quite High
Inflammation 7 43.52 Quite Low
Bile 1 19.28 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Eae 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 8 94.96 High High
Schizophrenia 2 94.36 High High
Stress 78 67.60 Quite High
Sepsis 2 63.32 Quite High
Affective Disorder 2 59.28 Quite High
Injury 2 59.08 Quite High
Infection 11 55.96 Quite High
Disease 3 46.68 Quite Low
INFLAMMATION 8 43.52 Quite Low
Anxiety Disorder 2 39.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study, we showed for the first time that activation of the Trp catabolism in BALB/c mice caused a peripheral accumulation of Kyna which is a (N-methyl-D-aspartat) NMDA receptor antagonist and is known to contribute to the development of disorders such as depression and schizophrenia [34].
Positive_regulation (activation) of Trp Positive_regulation (caused) of Positive_regulation (accumulation) of Kyna associated with nmda receptor antagonist, depression and schizophrenia
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.76 Pain Relevance 0.21

General Comments

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