INT323365

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 3.04
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neutrophils 6
monocyte 4
muscle 4
leukocytes 2
HIST2H2AA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 90 99.32 Very High Very High Very High
substance P 135 99.24 Very High Very High Very High
Inflammatory mediators 70 99.12 Very High Very High Very High
chemokine 45 95.96 Very High Very High Very High
qutenza 30 93.60 High High
agonist 10 93.20 High High
calcitonin gene related peptide 80 90.80 High High
Inflammation 275 86.00 High High
tetrodotoxin 15 85.32 High High
TRP channel 10 74.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 395 99.12 Very High Very High Very High
Cv Unclassified Under Development 50 91.56 High High
Congenital Anomalies 5 83.92 Quite High
Adhesions 90 81.76 Quite High
Esophageal Disease 110 70.32 Quite High
Gastroesophageal Reflux Disease 60 66.88 Quite High
Hyperplasia 5 56.36 Quite High
Reperfusion Injury 30 5.00 Very Low Very Low Very Low
Injury 30 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAF and SP activate peripheral blood leukocytes inducing the production of H2O2.
Positive_regulation (inducing) of Gene_expression (production) of H2O2 in leukocytes associated with substance p
1) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Abstract Doc Link PMC2978390 Disease Relevance 0.28 Pain Relevance 0.81
This indicates that PAF is a major mucosa-derived mediator depressing muscle contraction.41 PAF can also activate the esophageal circular muscle to secrete IL-6.41 The muscle-derived IL-6 then leads to enhanced production of H2O2, which in turn induces the secretion of IL-1.41,42 H2O2 and IL-1 can themselves induce PAF production (Fig. 13).
Positive_regulation (leads) of Gene_expression (production) of H2O2 in muscle
2) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.36 Pain Relevance 0.21
In contrast, a PAF antagonist and a neurokinin-1 receptor antagonist (ie, SP antagonist) significantly reduce supernatant-induced H2O2 production.
Positive_regulation (-) of Gene_expression (production) of H2O2 associated with antagonist and substance p
3) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.39 Pain Relevance 0.76
This indicates that PAF is a major mucosa-derived mediator depressing muscle contraction.41 PAF can also activate the esophageal circular muscle to secrete IL-6.41 The muscle-derived IL-6 then leads to enhanced production of H2O2, which in turn induces the secretion of IL-1.41,42 H2O2 and IL-1 can themselves induce PAF production (Fig. 13).
Positive_regulation (enhanced) of Gene_expression (production) of H2O2 in muscle
4) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.36 Pain Relevance 0.21
In contrast, a PAF antagonist and a neurokinin-1 receptor antagonist (ie, SP antagonist) significantly reduce supernatant-induced H2O2 production.
Positive_regulation (induced) of Gene_expression (production) of H2O2 associated with antagonist and substance p
5) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.39 Pain Relevance 0.76
This was indicated by the increase in intracellular H2O2 production of monocytes and neutrophils.
Positive_regulation (increase) of Gene_expression (production) of H2O2 in neutrophils
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.63 Pain Relevance 0.10
Results demonstrate that following tourniquet-applied upper limb orthopaedic surgery there was an increase in the intracellular H2O2 production of both neutrophils and monocytes (p<0.001), (Figure 3).
Positive_regulation (increase) of Gene_expression (production) of H2O2 in neutrophils
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0
Specifically, neutrophil intracellular H2O2 production increased from baseline (274.76±107.14), during 5 minutes (301.58±125.09) and 15 minutes (340.54±150.76) reperfusion, whilst monocyte intracellular H2O2 production increased from baseline (170.33±86.22), during 5 minutes (200.09±90.95) and 15 minutes (255.21±111.97) reperfusion.
Positive_regulation (increased) of Gene_expression (production) of H2O2 in monocyte
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0
This was indicated by the increase in intracellular H2O2 production of monocytes and neutrophils.
Positive_regulation (increase) of in monocytes Gene_expression (production) of H2O2 in neutrophils
9) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.63 Pain Relevance 0.10
Results demonstrate that following tourniquet-applied upper limb orthopaedic surgery there was an increase in the intracellular H2O2 production of both neutrophils and monocytes (p<0.001), (Figure 3).
Positive_regulation (increase) of in monocytes Gene_expression (production) of H2O2 in neutrophils
10) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0

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