INT323392

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.52
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SERPINH1, BCHE) extracellular space (BCHE) extracellular region (BCHE)
enzyme binding (BCHE) response to stress (SERPINH1)
SERPINH1 (Homo sapiens)
BCHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 3 75.52 Quite High
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
induced neuropathy 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 27 85.88 High High
Congenital Anomalies 6 84.72 Quite High
Drug Induced Neurotoxicity 18 83.28 Quite High
Toxicity 21 82.24 Quite High
Hepatotoxicity 24 5.00 Very Low Very Low Very Low
Freckles 15 5.00 Very Low Very Low Very Low
Cancer 15 5.00 Very Low Very Low Very Low
Acute Promyelocytic Leukemia 12 5.00 Very Low Very Low Very Low
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Neurological Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, arsenic reduces the activity of cholinesterase probably due to other mechanisms rather than the direct binding to the enzyme.
arsenic Negative_regulation (reduces) of cholinesterase
1) Confidence 0.02 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.29 Pain Relevance 0.04
The mechanisms for how arsenic decreases cholinesterase activity have not yet been documented.
arsenic Negative_regulation (decreases) of cholinesterase
2) Confidence 0.02 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0 Pain Relevance 0
While this manuscript was under preparation, Hernandez's et al. [37] reported that the activity of cholinesterase was not decreased by arsenic.
arsenic Neg (not) Negative_regulation (decreased) of cholinesterase
3) Confidence 0.02 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.23 Pain Relevance 0

General Comments

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