INT323431

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hif1a, Vhl) nucleus (Hif1a, Vhl) cell differentiation (Hif1a)
mitochondrion (Vhl) protein binding transcription factor activity (Hif1a) extracellular matrix organization (Vhl)
Hif1a (Mus musculus)
Vhl (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 100 81.76 Quite High
Inflammation 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 11 99.72 Very High Very High Very High
Cancer 70 86.92 High High
Targeted Disruption 17 71.04 Quite High
Peripheral Arterial Disease 2 48.44 Quite Low
Injury 8 42.88 Quite Low
Breast Cancer 5 5.00 Very Low Very Low Very Low
Wound Healing 3 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Gliosarcoma 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VHL cannot bind HIF-1 under hypoxic conditions, leading to stabilization of HIF-1 and downstream signaling [58].
HIF-1 Neg (cannot) Binding (bind) of VHL associated with hypoxia
1) Confidence 0.07 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.68 Pain Relevance 0.12

General Comments

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