INT323469

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.40
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
pancreas 2
Ghrl (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 219 100.00 Very High Very High Very High
Ventral tegmentum 204 100.00 Very High Very High Very High
antagonist 174 99.72 Very High Very High Very High
nMDA receptor antagonist 9 98.84 Very High Very High Very High
opioid receptor 24 98.60 Very High Very High Very High
Opioid 24 90.20 High High
Glutamate 18 84.80 Quite High
alcohol 21 82.08 Quite High
Eae 54 81.60 Quite High
Serotonin 3 80.56 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 86.96 High High
Hypoglycemia 6 84.12 Quite High
Hyperphagia 9 83.28 Quite High
Impaired Glucose Tolerance 60 83.04 Quite High
Insulin Resistance 54 58.40 Quite High
Hyperinsulinism 30 18.56 Low Low
Reprotox - General 1 3 16.24 Low Low
Obesity 150 13.56 Low Low
Targeted Disruption 162 5.00 Very Low Very Low Very Low
Body Weight 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the present study shows that the effects of peripheral ghrelin on locomotor stimulation and accumbal dopamine release in mice (that reflect direct actions of ghrelin at the level of the mesolimbic dopamine system, specifically the VTA) can be suppressed by an NMDA antagonist and are therefore likely to be under glutamatergic control.
Negative_regulation (suppressed) of Localization (release) of ghrelin associated with ventral tegmentum, dopamine and antagonist
1) Confidence 0.29 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0.08 Pain Relevance 0.73
Supportively, in the present study neither AP5 nor BIM28163 blocked ghrelin-induced locomotor stimulation nor accumbal dopamine release in a few mice in which the canulae were misplaced in neighbouring structures (data not shown).
Negative_regulation (blocked) of Localization (release) of ghrelin associated with dopamine and antagonist
2) Confidence 0.29 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.51
Finally, ghrelin-induced locomotor stimulation as well as accumbal dopamine release were suppressed by VTA administration of an NMDA receptor antagonist (AP5).
Negative_regulation (suppressed) of Localization (release) of ghrelin associated with ventral tegmentum, nmda receptor antagonist, dopamine and antagonist
3) Confidence 0.29 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 1.06
Doi et al. observed that ghrelin inhibits GSIS in MIN6 cells and that the concentrations of ghrelin inhibiting GSIS were very close to those of ghrelin enhancing IA-2?
Negative_regulation (close) of Localization (those) of ghrelin
4) Confidence 0.21 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.17 Pain Relevance 0.04
The results obtained with perfused rat pancreas support a role for ghrelin inhibiting insulin release.
Negative_regulation (inhibiting) of Localization (release) of ghrelin in pancreas
5) Confidence 0.21 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0.04
All the more hepatic vagotomy or coinfusion with atropine methyl bromide (a muscarinic antagonist) diminished the inhibitory effect of ghrelin on glucose-stimulated insulin secretion [70].
Negative_regulation (effect) of Localization (secretion) of ghrelin associated with antagonist
6) Confidence 0.21 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.14 Pain Relevance 0.12

General Comments

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