INT323470

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.94
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ghsr) plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
stomach 2
adipocyte 1
Ghsr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 56 99.42 Very High Very High Very High
isoflurane 3 66.00 Quite High
sodium channel 33 46.40 Quite Low
Kinase C 12 41.72 Quite Low
Somatostatin 16 23.20 Low Low
TRP channel 3 21.76 Low Low
tolerance 72 5.00 Very Low Very Low Very Low
Action potential 13 5.00 Very Low Very Low Very Low
Serotonin 12 5.00 Very Low Very Low Very Low
vagus nerve 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 225 100.00 Very High Very High Very High
Obesity 196 98.64 Very High Very High Very High
Aging 3 98.28 Very High Very High Very High
Reprotox - General 1 4 89.76 High High
Hyperinsulinism 40 79.20 Quite High
Salivary Gland Disease 6 78.00 Quite High
Body Weight 39 76.88 Quite High
Hyperglycemia 16 34.56 Quite Low
Diabetes Mellitus 120 33.24 Quite Low
Hypoglycemia 8 30.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects of UAG could not be antagonized by administration of synthetic GHSR1a antagonists [28] as UAG is unable to bind the classical GHSR1a, which recognizes ghrelin in its acylated form only [9].
GHSR1a Neg (unable) Binding (bind) of associated with antagonist
1) Confidence 0.40 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.09 Pain Relevance 0.05
Evidences that UAG is an active peptide implies the existence of GHSR subtypes that recognize and bind ghrelin independently of its acylation.
GHSR Neg (independently) Binding (bind) of
2) Confidence 0.40 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.08 Pain Relevance 0.04
Ghrelin, a 28-amino-acid peptide, is an orexigenic hormone that was first isolated from X/A cells in the stomach [20] and is a ligand for the growth hormone secretagogue receptor (GHSR) [21].
GHSR Binding (ligand) of in stomach
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.13 Pain Relevance 0
Ghrelin, a 28-amino-acid peptide, is an orexigenic hormone that was first isolated from X/A cells in the stomach [20] and is a ligand for the growth hormone secretagogue receptor (GHSR) [21].
secretagogue receptor Binding (ligand) of in stomach
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.13 Pain Relevance 0
Male ghrelin receptor knockout mice on a BL6/C57 background and their WT BL6/C57 counterparts were employed for our studies (n?
ghrelin receptor Binding (background) of associated with targeted disruption
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.35 Pain Relevance 0.03
Interestingly, ghrelin did not affect insulin-stimulated glucose uptake in perirenal adipocytes, which do not express GHSR1a, and des-acyl ghrelin, which does not bind to GHSR1a, did not influence insulin-stimulated glucose uptake in epididymal adipocytes The effects of ghrelin on adipocyte glucose uptake might be expected to result in fatty acid accumulation and an increase in adiposity in the long term [145].
GHSR1a Neg (not) Spec (might) Binding (bind) of in adipocyte associated with obesity
6) Confidence 0.30 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.88 Pain Relevance 0
It binds with high affinity to a receptor, different from GHSR1a and yet unknown [9, 12].
GHSR1a Binding (binds) of
7) Confidence 0.30 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.27 Pain Relevance 0

General Comments

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