INT323486

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.07
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, Ins1) extracellular region (Ghrl, Ins1) cytoplasm (Ghrl, Ins1)
carbohydrate metabolic process (Ins1)
Anatomy Link Frequency
pancreas 2
Ghrl (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 90 92.36 High High
antagonist 70 38.72 Quite Low
Somatostatin 20 5.00 Very Low Very Low Very Low
Kinase C 15 5.00 Very Low Very Low Very Low
vagus nerve 10 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Action potential 5 5.00 Very Low Very Low Very Low
Opioid 5 5.00 Very Low Very Low Very Low
Calcium channel 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 20 94.64 High High
Targeted Disruption 270 93.52 High High
Hyperinsulinism 50 93.20 High High
Impaired Glucose Tolerance 100 92.36 High High
Body Weight 45 90.44 High High
Obesity 245 81.20 Quite High
Metabolic Syndrome 5 71.92 Quite High
Insulin Resistance 90 60.32 Quite High
Body Weight Changes 5 59.28 Quite High
Lifespan 5 37.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, the data consistently suggest that ghrelin may be important in the control of glucose homeostasis and insulin release.
ghrelin Spec (may) Regulation (important) of Localization (release) of insulin
1) Confidence 0.21 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.55 Pain Relevance 0
These data could indicate a role for ghrelin in worsening insulin sensitivity.
ghrelin Regulation (role) of Localization (sensitivity) of insulin
2) Confidence 0.16 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.20 Pain Relevance 0
Egido et al. dissected and perfused in situ the pancreas of rats fed ad libitum; the addition of ghrelin to the perfusate did not significantly modify basal insulin release but markedly inhibited the insulin response to increasing glucose concentrations, arginine, and carbachol [90].
ghrelin Neg (not) Regulation (modify) of Localization (release) of insulin in pancreas
3) Confidence 0.08 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0
The results of GTTs and ITTs were similar to those previously observed for the same authors with pharmacological blockade of ghrelin action [58], reinforcing the concept that endogenous ghrelin serves as a regulator of insulin release and of glycemia.
ghrelin Regulation (regulator) of Localization (release) of insulin
4) Confidence 0.08 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.76 Pain Relevance 0.05
Hence these models can serve to study the role of desacyl as well as acylated ghrelin in the regulation of glucose metabolism and insulin release.
ghrelin Regulation (regulation) of Localization (release) of insulin
5) Confidence 0.08 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.56 Pain Relevance 0.03

General Comments

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