INT323487

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ghrl, Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytosol (Akt1)
Anatomy Link Frequency
adipocytes 2
Ghrl (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 19.72 Low Low
tolerance 18 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
vagus nerve 2 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Action potential 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 49 99.40 Very High Very High Very High
Diabetes Mellitus 30 57.92 Quite High
Hyperinsulinism 10 57.20 Quite High
Hyperglycemia 4 52.56 Quite High
Insulin Resistance 18 44.72 Quite Low
Disease 6 23.76 Low Low
Targeted Disruption 54 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 20 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Appetite Loss 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, ghrelin treatment induced increases IRS-1 and AKT phosphorylation, but when the adipocytes were treated with wortmannin, a PI3K inhibitor, completely blocked this ghrelin induced increase in glucose transport and phospho-AKT expression [146], suggesting that PI3K/AKT activation may mediate the effect of ghrelin on glucose transport in these adipocytes (Figure 3).
ghrelin Positive_regulation (induced) of Phosphorylation (phosphorylation) of AKT in adipocytes associated with obesity
1) Confidence 0.09 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.77 Pain Relevance 0

General Comments

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