INT323491

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.87
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) signal transduction (Olfr781) extracellular region (Ins1)
carbohydrate metabolic process (Ins1) cytoplasm (Ins1) signal transducer activity (Olfr781)
Olfr781 (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 18 100.00 Very High Very High Very High
antagonist 14 99.98 Very High Very High Very High
Somatostatin 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
vagus nerve 2 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Action potential 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 20 100.00 Very High Very High Very High
Disease 6 90.40 High High
Obesity 49 84.64 Quite High
Diabetes Mellitus 30 55.60 Quite High
Insulin Resistance 18 54.48 Quite High
Liver Failure 2 14.48 Low Low
Targeted Disruption 54 5.00 Very Low Very Low Very Low
Hyperinsulinism 10 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Appetite Loss 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result, in combination with the effect of the compound on insulin secretion, demonstrates that, at least acutely, the GHSR1a antagonist YIL-781 improves glucose tolerance by promoting insulin release rather than enhancing insulin sensitivity.
YIL-781 Positive_regulation (promoting) of Localization (release) of insulin associated with antagonist, tolerance and impaired glucose tolerance
1) Confidence 0.01 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.87 Pain Relevance 0.40

General Comments

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