INT323494

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.12
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, Ins1) extracellular region (Ghrl, Ins1) cytoplasm (Ghrl, Ins1)
carbohydrate metabolic process (Ins1)
Anatomy Link Frequency
adipocytes 1
Ghrl (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 70 84.40 Quite High
Kinase C 15 73.08 Quite High
tolerance 90 65.88 Quite High
vagus nerve 10 17.56 Low Low
Somatostatin 20 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Action potential 5 5.00 Very Low Very Low Very Low
Opioid 5 5.00 Very Low Very Low Very Low
Calcium channel 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 50 98.00 Very High Very High Very High
Obesity 245 97.80 Very High Very High Very High
Targeted Disruption 270 96.24 Very High Very High Very High
Diabetes Mellitus 150 75.36 Quite High
Metabolic Syndrome 5 71.92 Quite High
Impaired Glucose Tolerance 100 65.88 Quite High
Body Weight 45 53.80 Quite High
Bordatella Infection 5 53.04 Quite High
Insulin Resistance 90 45.96 Quite Low
Congenital Anomalies 5 26.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, the ghrelin/GHSR pathway plays a role in glucose homeostasis by regulating insulin sensitivity and glucose sensing.
ghrelin Regulation (regulating) of insulin
1) Confidence 0.16 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.54 Pain Relevance 0.07
Des-acyl ghrelin had no significant effect on insulin-stimulated deoxyglucose uptake in isolated epididymal adipocytes.
ghrelin Neg (no) Regulation (effect) of insulin in adipocytes associated with obesity
2) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.79 Pain Relevance 0.04
However the effects of endogenous and exogenous ghrelin on insulin levels were not observed in PTX-treated rats.
ghrelin Regulation (effects) of insulin
3) Confidence 0.09 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.24 Pain Relevance 0.04
But long-term effects of exogenous ghrelin on glucose and insulin levels are not conclusive; there are differences inter-experiments which could reflect different doses, administration way, and/or species used.
ghrelin Regulation (effects) of insulin
4) Confidence 0.09 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0
Hence these models can serve to study the role of desacyl as well as acylated ghrelin in the regulation of glucose metabolism and insulin release.
ghrelin Regulation (regulation) of insulin
5) Confidence 0.08 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.56 Pain Relevance 0.03

General Comments

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