INT323499

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, Ins1) extracellular region (Ghrl, Ins1) cytoplasm (Ghrl, Ins1)
carbohydrate metabolic process (Ins1)
Ghrl (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 18 8.68 Low Low
antagonist 14 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
vagus nerve 2 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Action potential 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 2 99.76 Very High Very High Very High
Starvation 1 53.80 Quite High
Hyperphagia 1 27.36 Quite Low
Targeted Disruption 54 23.52 Low Low
Impaired Glucose Tolerance 20 8.68 Low Low
Obesity 49 5.00 Very Low Very Low Very Low
Diabetes Mellitus 30 5.00 Very Low Very Low Very Low
Insulin Resistance 18 5.00 Very Low Very Low Very Low
Hyperinsulinism 10 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the H4-II-E-cells (rat hepatoma cell line) and HepG2 cells (human hepatocellular carcinoma cell line) ghrelin was shown to stimulate insulin receptor substrate 1ยบ(IRS1) and its downstream molecules, including growth factor receptor-bound protein 2 (Grb2) and mitogen-activated protein kinase (MAPK).
ghrelin Positive_regulation (stimulate) of insulin associated with hepatocellular cancer
1) Confidence 0.21 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.25 Pain Relevance 0

General Comments

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