INT323500

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ghrl, Grb2) cell differentiation (Grb2) endosome (Grb2)
anatomical structure formation involved in morphogenesis (Grb2) aging (Grb2) Golgi apparatus (Grb2)
Ghrl (Mus musculus)
Grb2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 36 8.68 Low Low
antagonist 28 5.00 Very Low Very Low Very Low
Somatostatin 8 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
vagus nerve 4 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 4 99.76 Very High Very High Very High
Starvation 2 53.80 Quite High
Hyperphagia 2 27.36 Quite Low
Targeted Disruption 108 23.52 Low Low
Impaired Glucose Tolerance 40 8.68 Low Low
Obesity 98 5.00 Very Low Very Low Very Low
Diabetes Mellitus 60 5.00 Very Low Very Low Very Low
Insulin Resistance 36 5.00 Very Low Very Low Very Low
Hyperinsulinism 20 5.00 Very Low Very Low Very Low
Body Weight 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the H4-II-E-cells (rat hepatoma cell line) and HepG2 cells (human hepatocellular carcinoma cell line) ghrelin was shown to stimulate insulin receptor substrate 1º(IRS1) and its downstream molecules, including growth factor receptor-bound protein 2 (Grb2) and mitogen-activated protein kinase (MAPK).
ghrelin Positive_regulation (stimulate) of growth factor receptor-bound protein 2 associated with hepatocellular cancer
1) Confidence 0.13 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.25 Pain Relevance 0
In the H4-II-E-cells (rat hepatoma cell line) and HepG2 cells (human hepatocellular carcinoma cell line) ghrelin was shown to stimulate insulin receptor substrate 1º(IRS1) and its downstream molecules, including growth factor receptor-bound protein 2 (Grb2) and mitogen-activated protein kinase (MAPK).
ghrelin Positive_regulation (stimulate) of Grb2 associated with hepatocellular cancer
2) Confidence 0.13 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.25 Pain Relevance 0

General Comments

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