INT323502

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.58
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, Ins1) extracellular region (Ghrl, Ins1) cytoplasm (Ghrl, Ins1)
carbohydrate metabolic process (Ins1)
Anatomy Link Frequency
blood 2
pancreas 2
Ghrl (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 72 97.70 Very High Very High Very High
antagonist 56 85.56 High High
vagus nerve 8 68.16 Quite High
Kinase C 12 61.68 Quite High
Somatostatin 16 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 16 100.00 Very High Very High Very High
Hyperinsulinism 40 99.58 Very High Very High Very High
Impaired Glucose Tolerance 80 97.70 Very High Very High Very High
Obesity 196 96.36 Very High Very High Very High
Diabetes Mellitus 120 94.48 High High
Disease 24 93.64 High High
Appetite Loss 20 85.16 High High
Insulin Resistance 72 74.92 Quite High
Liver Failure 8 36.68 Quite Low
Targeted Disruption 216 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, insulin increased glucose uptake, but ghrelin in the presence of insulin did not further increase this response.
ghrelin Neg (not) Positive_regulation (increase) of Localization (presence) of insulin associated with hyperinsulinism
1) Confidence 0.15 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.90 Pain Relevance 0.03
It was observed that the glucose-induced insulin release from the rat-perfused pancreas was markedly enhanced by blockade of GHSR and immunoneutralization of endogenous ghrelin.
ghrelin Positive_regulation (enhanced) of Localization (release) of insulin in pancreas
2) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0.03
The first studies with ghrelin showed that acute ghrelin treatment induced hyperglycemia and reduced insulin secretion in healthy humans [65] during the first hours of treatment.
ghrelin Positive_regulation (induced) of Localization (secretion) of insulin associated with hyperglycemia
3) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.45 Pain Relevance 0.03
Similarly during the intraperitoneal glucose tolerance test (IP-GTT), plasma glucose elevation was attenuated and insulin response was enhanced, showing a physiological role for endogenous ghrelin in the regulation of insulin release and blood glucose [58].
ghrelin Positive_regulation (role) of Localization (release) of insulin in blood associated with tolerance and impaired glucose tolerance
4) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.23 Pain Relevance 0.23

General Comments

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