INT323611

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.36
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
microglia 1
Il1 (Mus musculus)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 26 99.48 Very High Very High Very High
cytokine 70 98.00 Very High Very High Very High
Inflammation 36 96.08 Very High Very High Very High
Inflammatory marker 4 93.40 High High
long-term potentiation 2 90.40 High High
Glutamate 2 56.12 Quite High
Central nervous system 14 47.00 Quite Low
Inflammatory response 14 43.28 Quite Low
Inflammatory mediators 4 40.64 Quite Low
Hyperalgesia 2 16.12 Low Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 74 100.00 Very High Very High Very High
Congenital Anomalies 4 100.00 Very High Very High Very High
Endotoxemia 8 98.16 Very High Very High Very High
INFLAMMATION 58 96.08 Very High Very High Very High
Delirium 4 87.76 High High
Sepsis 14 87.24 High High
Critical Illness 2 80.56 Quite High
Dementia 2 77.88 Quite High
Disease 4 75.36 Quite High
Shock 6 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we provide evidence that targeting the IL-1 signaling ameliorates cognitive abnormalities that does not directly depend on HMGB-1 mechanisms.
IL-1 Neg (not) Regulation (depend) of HMGB-1 associated with cognitive disorder and congenital anomalies
1) Confidence 0.17 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 1.46 Pain Relevance 0.25
Targeting IL-1 ameliorates the cognitive abnormality by reducing microglia but does not affect HMGB1
IL-1 Neg (not) Regulation (affect) of HMGB1 in microglia associated with cognitive disorder
2) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.90 Pain Relevance 0.30

General Comments

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