INT323613

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
microglia 2
Il1 (Mus musculus)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 35 86.80 High High
Inflammation 18 79.12 Quite High
Central nervous system 7 71.52 Quite High
Inflammatory response 7 49.80 Quite Low
Inflammatory mediators 2 26.32 Quite Low
Hippocampus 13 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 37 99.50 Very High Very High Very High
INFLAMMATION 29 79.12 Quite High
Sepsis 7 70.92 Quite High
Multiple Organ Failure 2 66.72 Quite High
Stress 2 51.52 Quite High
Cancer 2 49.36 Quite Low
Necrosis 2 48.88 Quite Low
Injury 3 44.80 Quite Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low
Endotoxemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Key messages

• Neuroinflammation plays a pivotal role in mediating physiological and behavioral changes after LPS. • Up-regulation of microglia and HMGB-1 correlates in a temporal fashion with the cognitive dysfunction. • Blocking IL-1 does not affect HMGB-1 release; however, it reduces microglia activation reversing the behavioral abnormality. • In the absence of IL-1, HMGB-1 is insufficient to sustain hippocampal neuroinflammation and the attendant cognitive dysfunction.

IL-1 Neg (not) Regulation (affect) of Localization (release) of HMGB-1 in microglia associated with cognitive disorder
1) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.75 Pain Relevance 0.19

General Comments

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