INT323715

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.22

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Anatomy Link Frequency
blood 1
MIR512-2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 56 97.64 Very High Very High Very High
cytokine 12 6.96 Low Low
Inflammation 13 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 56 97.64 Very High Very High Very High
Apoptosis 24 34.96 Quite Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Autoimmune Disease 6 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with normal peripheral blood CD4+ T cells, pairwise significance analysis of microarray data indicated that the expression levels of eight miRNAs (miR-363, miR-512-5P, miR-345-MM, miR-146a, miR-146b, miR-296, miR-133b and miR-150) were increased more than two-fold by a change in CD4+ T cells of SF from RA patients whereas eight miRNAs (miR-331, miR-29a, miR-26a, miR-498, miR-129, let-7a, let-7d and miR-21) were significantly downregulated (Figure 1a).
Positive_regulation (increased) of miR-512-5P in blood associated with rheumatoid arthritis
1) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.43 Pain Relevance 0.22

General Comments

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