INT323729

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.04
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

MIR146A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 250 98.92 Very High Very High Very High
Osteoarthritis 50 98.44 Very High Very High Very High
Inflammation 50 71.84 Quite High
cytokine 36 68.64 Quite High
cINOD 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 70 99.60 Very High Very High Very High
Rheumatoid Arthritis 250 98.92 Very High Very High Very High
Osteoarthritis 48 98.44 Very High Very High Very High
Repression 10 73.56 Quite High
INFLAMMATION 52 71.84 Quite High
Apoptosis 50 58.48 Quite High
Death 12 49.36 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 44.32 Quite Low
Autoimmune Disease 12 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression level of miR-146a and IL-17 in patient RA1 and RA4 was high in comparison to the other patients. miR-146a expressed intensely with IL-17 expression in PBMC from the patients with early stage of RA and high disease activity (Figure 2B).


Negative_regulation (level) of miR-146a associated with rheumatoid arthritis and disease
1) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.60 Pain Relevance 0.74
Cloning of miR-146a gene and construction of vectors
Negative_regulation (Cloning) of miR-146a
2) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0 Pain Relevance 0
As many genes such as IRAK1, IRAK2, TRAF6, FADD, IRF-5, STAT-1 and PTC1 have been found to be targets of miR-146a in human disease [20,31,34,46], the targets and functions of miR-146a may be different in specific cells.
Negative_regulation (targets) of miR-146a associated with disease
3) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.36 Pain Relevance 0.03
The expression level of miR-26a, miR-146a/b, miR-150 and miR-155 in RA patients were significantly higher than in healthy subjects.
Negative_regulation (level) of miR-146a associated with rheumatoid arthritis
4) Confidence 0.09 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.09 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox