INT323736

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 8.30
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 5
blood 1
memory T cells 1
MIR146A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 586 99.44 Very High Very High Very High
Inflammation 128 93.24 High High
cytokine 108 89.72 High High
Osteoarthritis 50 89.00 High High
psoriasis 16 81.36 Quite High
tolerance 8 78.68 Quite High
Multiple sclerosis 4 69.84 Quite High
cINOD 12 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 586 99.44 Very High Very High Very High
Autoimmune Disease 48 99.00 Very High Very High Very High
Apoptosis 194 98.72 Very High Very High Very High
Disease 124 98.36 Very High Very High Very High
Lymphoproliferative Disease 8 98.08 Very High Very High Very High
INFLAMMATION 130 93.24 High High
Viral Infection 12 92.60 High High
Cancer 30 91.32 High High
Osteoarthritis 48 89.00 High High
Systemic Lupus Erythematosus 16 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the expression of two targets of miR-146, TRAF6 and IL-1 receptor-associated kinase 1, remains unchanged although miR-146 is upregulated in PBMC from RA patients [22].
Positive_regulation (upregulated) of miR-146 associated with rheumatoid arthritis
1) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.75 Pain Relevance 0.12
Paulay et al. reported that PBMCs from RA patients exhibit statistically significant increase the expression levels of miR-146a, miR-155, miR-132, and miR-16 in comparison to healthy and disease control individuals.
Positive_regulation (increase) of miR-146a associated with rheumatoid arthritis and disease
2) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.68 Pain Relevance 0.48
MiR-146a and miR-146b increased by a factor of six in comparison to non-expanded cells.
Positive_regulation (increased) of MiR-146a
3) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0 Pain Relevance 0
Compared with normal peripheral blood CD4+ T cells, pairwise significance analysis of microarray data indicated that the expression levels of eight miRNAs (miR-363, miR-512-5P, miR-345-MM, miR-146a, miR-146b, miR-296, miR-133b and miR-150) were increased more than two-fold by a change in CD4+ T cells of SF from RA patients whereas eight miRNAs (miR-331, miR-29a, miR-26a, miR-498, miR-129, let-7a, let-7d and miR-21) were significantly downregulated (Figure 1a).
Positive_regulation (increased) of miR-146a in blood associated with rheumatoid arthritis
4) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.43 Pain Relevance 0.22
Thus, our findings that miR-146a upregulation in CD4+ T cells is correlated with increased TNF-?
Positive_regulation (upregulation) of miR-146a in T cells
5) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.91 Pain Relevance 0.24
Recently, upregulated miR-146a has been found in activated primary T cells and memory T cells [31].
Positive_regulation (upregulated) of miR-146a in T cells
6) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 1.04 Pain Relevance 0.10
We have detected increased miR-146a in CD4+ T cells of RA patients and its close correlation with TNF-?
Positive_regulation (increased) of miR-146a in T cells associated with rheumatoid arthritis
7) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911863 Disease Relevance 0.76 Pain Relevance 0.20
Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis

Introduction

Positive_regulation (upregulation) of miR-146a in T cells associated with rheumatoid arthritis
8) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Title Doc Link PMC2911863 Disease Relevance 0.78 Pain Relevance 0.29
Although our current data confirm the increased miR-146a levels in synovial and peripheral blood CD4+T cells of RA patients, we were not able to differentiate the expression pattern of miR-146a levels in various CD4+T cell subpopulations due to the limited numbers of synovial and peripheral blood CD4+T cells.
Positive_regulation (increased) of miR-146a in T cells associated with rheumatoid arthritis
9) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.91 Pain Relevance 0.46
Recently, upregulated miR-146a has been found in activated primary T cells and memory T cells [31].
Positive_regulation (upregulated) of miR-146a in memory T cells
10) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 1.04 Pain Relevance 0.10

General Comments

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