INT323739

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.73
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRAK1) signal transduction (IRAK1) plasma membrane (IRAK1)
nucleus (IRAK1) kinase activity (IRAK1) cytoplasm (IRAK1)
Anatomy Link Frequency
T cells 1
IRAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 181 97.40 Very High Very High Very High
Osteoarthritis 25 82.96 Quite High
tolerance 2 82.36 Quite High
Inflammation 38 41.36 Quite Low
cytokine 30 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 99.12 Very High Very High Very High
Rheumatoid Arthritis 181 97.40 Very High Very High Very High
Death 12 86.08 High High
Osteoarthritis 24 82.96 Quite High
Repression 8 76.44 Quite High
Apoptosis 49 75.08 Quite High
Autoimmune Disease 12 59.52 Quite High
INFLAMMATION 39 41.36 Quite Low
Cancer 9 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, western blotting revealed that IRAK1 was down regulated in expanded IL-17 producing T cells in protein level (Figure 1C).


Regulation (regulated) of IRAK1 in T cells
1) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.57 Pain Relevance 0.28
Interestingly, the expression of two targets of miR-146, TRAF6 and IL-1 receptor-associated kinase 1, remains unchanged although miR-146 is upregulated in PBMC from RA patients [22].
Regulation (targets) of IL-1 receptor-associated kinase 1 associated with rheumatoid arthritis
2) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.81 Pain Relevance 0.12
As many genes such as IRAK1, IRAK2, TRAF6, FADD, IRF-5, STAT-1 and PTC1 have been found to be targets of miR-146a in human disease [20,31,34,46], the targets and functions of miR-146a may be different in specific cells.
Regulation (targets) of IRAK1 associated with disease
3) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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