INT323741

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.94
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 4
synovium 2
MIR146A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 319 99.80 Very High Very High Very High
Osteoarthritis 75 98.88 Very High Very High Very High
Inflammation 62 95.04 Very High Very High Very High
cytokine 42 91.84 High High
cINOD 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Rheumatism 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 319 99.80 Very High Very High Very High
Osteoarthritis 72 98.88 Very High Very High Very High
Disease 96 98.00 Very High Very High Very High
INFLAMMATION 65 95.04 Very High Very High Very High
Apoptosis 51 73.32 Quite High
Autoimmune Disease 12 30.16 Quite Low
Cancer 15 8.72 Low Low
Viral Infection 8 6.88 Low Low
Hypersensitivity 15 5.00 Very Low Very Low Very Low
Repression 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression level of miR-26a, miR-146a/b, miR-150 and miR-155 in RA patients were significantly higher than in healthy subjects.
Negative_regulation (level) of Gene_expression (expression) of miR-146a associated with rheumatoid arthritis
1) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.09 Pain Relevance 0.54
The synovium from RA patients exhibit increased expression of miR-146a,b, 150, and 155
Negative_regulation (exhibit) of Gene_expression (expression) of miR-146a in synovium associated with rheumatoid arthritis
2) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.75 Pain Relevance 0.80
The expression level of miR-146a and IL-17 in patient RA1 and RA4 was high in comparison to the other patients. miR-146a expressed intensely with IL-17 expression in PBMC from the patients with early stage of RA and high disease activity (Figure 2B).


Negative_regulation (level) of Gene_expression (expression) of miR-146a associated with rheumatoid arthritis and disease
3) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.60 Pain Relevance 0.74
We transfected the miRNA sponge into Jurkat T cells and compared the gene expression profiles when miR-146a expression was up- and down-regulated.
Negative_regulation (regulated) of Gene_expression (expression) of miR-146a in T cells
4) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.25 Pain Relevance 0.06
We transfected the miRNA sponge into Jurkat T cells and compared the gene expression profiles when miR-146a expression was up- and down-regulated.
Negative_regulation (down) of Gene_expression (expression) of miR-146a in T cells
5) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.24 Pain Relevance 0.06

General Comments

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