From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.33
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRAK1) signal transduction (IRAK1) plasma membrane (IRAK1)
nucleus (IRAK1) kinase activity (IRAK1) cytoplasm (IRAK1)
Anatomy Link Frequency
biliary epithelium 1
IRAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 15 99.44 Very High Very High Very High
Inflammatory marker 2 99.14 Very High Very High Very High
rheumatoid arthritis 127 97.40 Very High Very High Very High
antagonist 4 82.76 Quite High
cytokine 112 71.68 Quite High
chemokine 20 66.88 Quite High
Inflammatory mediators 6 50.44 Quite High
agonist 108 46.80 Quite Low
Inflammatory response 30 44.12 Quite Low
Inflammation 157 41.36 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 186 98.98 Very High Very High Very High
Rheumatoid Arthritis 127 97.40 Very High Very High Very High
Infection 25 92.56 High High
Death 8 86.80 High High
Apoptosis 51 75.80 Quite High
Disease 51 74.32 Quite High
Autoimmune Disease 8 59.52 Quite High
Injury 62 50.00 Quite Low
Adhesions 14 47.96 Quite Low
Repression 5 42.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the expression of two targets of miR-146, TRAF6 and IL-1 receptor-associated kinase 1, remains unchanged although miR-146 is upregulated in PBMC from RA patients [22].
Gene_expression (expression) of IL-1 receptor-associated kinase 1 associated with rheumatoid arthritis
1) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.81 Pain Relevance 0.12
There was no significant difference in the expression level of IRAK1 between the expanded and non expanded cells at the mRNA level.
Gene_expression (expression) of IRAK1
2) Confidence 0.40 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.27 Pain Relevance 0.06
The tolerance is possibly induced by the expression of IRAK-M in the intrahepatic biliary epithelium [78].

Gene_expression (expression) of IRAK in biliary epithelium associated with tolerance
3) Confidence 0.35 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.09 Pain Relevance 0.23
This effect is mediated through the TLR4-PI3K-AKT signaling pathway, as the induction of inflammatory markers was also inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6 or I?
Gene_expression (mutant) of IRAK-1 associated with inflammatory marker
4) Confidence 0.30 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.15 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools