INT323870

Context Info Confidence 0.21 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.76 Pain Relevance 0.33

extracellular space (LEP, MMP13) extracellular region (LEP, MMP13) peptidase activity (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

Anatomy Link Frequency chondrocytes 2 LEP (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 108 97.36 cytokine 2 91.80 Inflammatory mediators 4 68.56 Inflammation 12 52.04 metalloproteinase 6 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Obesity 208 99.78 Osteoarthritis 108 97.36 Overweight 26 82.32 INFLAMMATION 14 68.16 Arthritis 2 52.04 Body Weight 4 5.00 Pain 2 5.00 Pressure And Volume Under Development 2 5.00 Weight Loss 2 5.00 Starvation 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One of the most relevant findings arising from this study is the BMI-dependent effect of leptin on the expression of the genes encoding TIMP-2 and MMP-13 in chondrocytes.

leptin Regulation (effect) of Gene_expression (expression) of MMP-13 in chondrocytes associated with obesity

1) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.64 Pain Relevance 0.21

In addition, the BMI-dependent effect of leptin for the expression of TIMP-2 and MMP-13 may explain why obesity is associated with an increased risk for OA.

leptin Regulation (effect) of Gene_expression (expression) of MMP-13 associated with obesity and osteoarthritis

2) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911905 Disease Relevance 1.13 Pain Relevance 0.12

General Comments

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