INT323873

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LEP, TIMP2) extracellular space (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
chondrocytes 2
LEP (Homo sapiens)
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1 91.80 High High
Osteoarthritis 54 76.56 Quite High
Inflammatory mediators 2 68.56 Quite High
Inflammation 6 52.04 Quite High
metalloproteinase 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 104 99.78 Very High Very High Very High
Osteoarthritis 54 76.56 Quite High
INFLAMMATION 7 68.16 Quite High
Overweight 13 55.68 Quite High
Arthritis 1 52.04 Quite High
Body Weight 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low
Starvation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the most relevant findings arising from this study is the BMI-dependent effect of leptin on the expression of the genes encoding TIMP-2 and MMP-13 in chondrocytes.
leptin Regulation (effect) of Gene_expression (expression) of TIMP-2 in chondrocytes associated with obesity
1) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.63 Pain Relevance 0.21

General Comments

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