INT323875

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.20
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
nucleolus (BMI1) nucleus (BMI1) cytoplasm (BMI1)
Anatomy Link Frequency
chondrocytes 1
BMI1 (Homo sapiens)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 54 86.40 High High
Inflammatory mediators 2 45.52 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 104 100.00 Very High Very High Very High
Osteoarthritis 54 86.40 High High
Overweight 13 79.04 Quite High
INFLAMMATION 7 45.12 Quite Low
Body Weight 2 37.20 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low
Starvation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on this BMI-dependent leptin dose-response of chondrocytes, we demonstrated that the stimulatory effect of leptin at 100 ng/ml on the expression of IGF-1, collagen type 2 and TIMP-2 was negatively related to the BMI of the patients while a positive association between chondrocyte responsiveness and BMI was found at 500 ng/ml of leptin for IGF-1, collagen type 2 and MMP-13 (Figure 3).


BMI Binding (association) of IGF-1 in chondrocytes associated with obesity
1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.20 Pain Relevance 0.11

General Comments

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