INT323880

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.97
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) nucleolus (BMI1)
nucleus (BMI1) lipid metabolic process (LEP) cytoplasm (BMI1)
Anatomy Link Frequency
chondrocytes 3
BMI1 (Homo sapiens)
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 162 92.08 High High
Inflammation 18 70.64 Quite High
Inflammatory mediators 6 51.20 Quite High
metalloproteinase 9 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 312 100.00 Very High Very High Very High
Osteoarthritis 162 92.08 High High
Overweight 39 84.72 Quite High
INFLAMMATION 21 70.64 Quite High
Body Weight 6 36.40 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Weight Loss 3 5.00 Very Low Very Low Very Low
Starvation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on this BMI-dependent leptin dose-response of chondrocytes, we demonstrated that the stimulatory effect of leptin at 100 ng/ml on the expression of IGF-1, collagen type 2 and TIMP-2 was negatively related to the BMI of the patients while a positive association between chondrocyte responsiveness and BMI was found at 500 ng/ml of leptin for IGF-1, collagen type 2 and MMP-13 (Figure 3).


BMI Binding (association) of leptin in chondrocytes associated with obesity
1) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.20 Pain Relevance 0.11
Based on this BMI-dependent leptin dose-response of chondrocytes, we demonstrated that the stimulatory effect of leptin at 100 ng/ml on the expression of IGF-1, collagen type 2 and TIMP-2 was negatively related to the BMI of the patients while a positive association between chondrocyte responsiveness and BMI was found at 500 ng/ml of leptin for IGF-1, collagen type 2 and MMP-13 (Figure 3).


BMI Binding (association) of leptin in chondrocytes associated with obesity
2) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.30 Pain Relevance 0.14
However, the activity of the adipokine was shown to be critically dependent on both the concentration and the BMI of the patients with a negative association between the activation of regulated genes and BMI for 100 ng/ml of adipokine, but a positive association between chondrocyte responsiveness and BMI for the highest leptin dose.
BMI Binding (association) of leptin in chondrocyte associated with obesity
3) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911905 Disease Relevance 1.47 Pain Relevance 0.17

General Comments

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