INT323882

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.26 Pain Relevance 0.11

Golgi apparatus (MMP13) cytoplasm (BMI1) peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) nucleolus (BMI1)

Anatomy Link Frequency chondrocytes 1 BMI1 (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 54 86.40 Inflammatory mediators 2 45.52 Inflammation 6 5.00 metalloproteinase 3 5.00 cytokine 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Obesity 104 100.00 Osteoarthritis 54 86.40 Overweight 13 79.04 INFLAMMATION 7 45.12 Body Weight 2 39.44 Pain 1 5.00 Arthritis 1 5.00 Pressure And Volume Under Development 1 5.00 Weight Loss 1 5.00 Starvation 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Based on this BMI-dependent leptin dose-response of chondrocytes, we demonstrated that the stimulatory effect of leptin at 100 ng/ml on the expression of IGF-1, collagen type 2 and TIMP-2 was negatively related to the BMI of the patients while a positive association between chondrocyte responsiveness and BMI was found at 500 ng/ml of leptin for IGF-1, collagen type 2 and MMP-13 (Figure 3).

BMI Binding (association) of MMP-13 in chondrocytes associated with obesity

1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.26 Pain Relevance 0.11

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