INT323886

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.13 Pain Relevance 0.12

Golgi apparatus (MMP13) cytoplasm (BMI1) peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) nucleolus (BMI1)

BMI1 (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 54 97.36 Inflammation 6 40.96 metalloproteinase 3 5.00 Inflammatory mediators 2 5.00 cytokine 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Obesity 104 100.00 Osteoarthritis 54 97.36 Overweight 13 82.88 INFLAMMATION 7 40.96 Body Weight 2 5.00 Pain 1 5.00 Arthritis 1 5.00 Pressure And Volume Under Development 1 5.00 Weight Loss 1 5.00 Starvation 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, the BMI-dependent effect of leptin for the expression of TIMP-2 and MMP-13 may explain why obesity is associated with an increased risk for OA.

BMI Regulation (effect) of Gene_expression (expression) of MMP-13 associated with obesity and osteoarthritis

1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911905 Disease Relevance 1.13 Pain Relevance 0.12

General Comments

This test has worked.