INT32389

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1983
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 7.23
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 2
Spinal 1
blood 1
spinal cord 1
pituitary 1
ecs (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 17 100.00 Very High Very High Very High
cytokine 18 99.84 Very High Very High Very High
Enkephalin 11 99.50 Very High Very High Very High
antidepressant 2 99.44 Very High Very High Very High
Pain 8 98.32 Very High Very High Very High
Dynorphin 18 97.92 Very High Very High Very High
Inflammation 25 97.72 Very High Very High Very High
Demyelination 1 96.76 Very High Very High Very High
Multiple sclerosis 8 96.32 Very High Very High Very High
Spinal cord 8 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 24 100.00 Very High Very High Very High
Convulsion 7 100.00 Very High Very High Very High
Neurological Disease 1 99.88 Very High Very High Very High
Spasticity 5 99.56 Very High Very High Very High
Cancer 175 99.40 Very High Very High Very High
Pain 8 98.32 Very High Very High Very High
INFLAMMATION 22 97.72 Very High Very High Very High
Neuropathic Pain 9 97.16 Very High Very High Very High
Demyelinating Disease 9 96.76 Very High Very High Very High
Urological Neuroanatomy 3 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of ECs are tightly controlled by enzymatic biosynthesis and degradation in vivo.
Regulation (controlled) of ECs associated with endocannabinoid
1) Confidence 0.49 Published 2010 Journal J Mass Spectrom Section Abstract Doc Link 19950120 Disease Relevance 0.10 Pain Relevance 0.24
Recent studies also indicate that diffusion in the ECS is affected by ECS volume inhomogeneities, which are the result of a more compacted space in certain regions, e.g. in the vicinity of oligodendrocytes.
Regulation (affected) of ECS in oligodendrocytes
2) Confidence 0.23 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10733007 Disease Relevance 0.61 Pain Relevance 0.34
Measurement of brain enkephalin levels revealed an increase in enkephalin contents after 10 daily ECS applications, an effect which was not affected by naltrexone pretreatment.
Neg (not) Regulation (affected) of ECS in brain associated with shock and enkephalin
3) Confidence 0.16 Published 1983 Journal Brain Res. Section Abstract Doc Link 6299458 Disease Relevance 1.13 Pain Relevance 1.81
As a consequence, elements of blood ECS might serve as novel, non-invasive diagnostic tools of several neurological disorders, and targeting the ECS might be useful for therapeutic purposes.
Regulation (targeting) of ECS in blood associated with neurological disease
4) Confidence 0.14 Published 2008 Journal Curr. Pharm. Des. Section Abstract Doc Link 18781987 Disease Relevance 0.33 Pain Relevance 0.34
The effects of single and repeated maximal electroconvulsive shock (ECS, 150 mA, 50 Hz, 0.5 s) on the immunoreactive (ir-) dynorphin and beta-endorphin level in the rat brain, spinal cord and pituitary were studied.
Regulation (effects) of ECS in brain associated with dynorphin, shock and spinal cord
5) Confidence 0.10 Published 1987 Journal Brain Res. Section Abstract Doc Link 2950968 Disease Relevance 0.17 Pain Relevance 0.24
The present study examines the influence of electroconvulsive seizure (ECS), as well as antidepressant drugs, on levels of serotonin2 (5-HT2) receptor mRNA in rat frontal cortex.
Spec (examines) Regulation (influence) of ECS in frontal cortex associated with antidepressant, convulsion and urological neuroanatomy
6) Confidence 0.08 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.64 Pain Relevance 0.15
The effects of single and repeated maximal electroconvulsive shock (ECS, 150 mA, 50 Hz, 0.5 s) on the immunoreactive (ir-) dynorphin and beta-endorphin level in the rat brain, spinal cord and pituitary were studied.
Regulation (effects) of ECS in spinal cord associated with dynorphin, shock and spinal cord
7) Confidence 0.04 Published 1987 Journal Brain Res. Section Abstract Doc Link 2950968 Disease Relevance 0.17 Pain Relevance 0.24
The effects of single and repeated maximal electroconvulsive shock (ECS, 150 mA, 50 Hz, 0.5 s) on the immunoreactive (ir-) dynorphin and beta-endorphin level in the rat brain, spinal cord and pituitary were studied.
Regulation (effects) of ECS in pituitary associated with dynorphin, shock and spinal cord
8) Confidence 0.04 Published 1987 Journal Brain Res. Section Abstract Doc Link 2950968 Disease Relevance 0.17 Pain Relevance 0.24
In 20 MS patients, we measured the effects of Sativex on clinically measured spasticity and on neurophysiological and laboratory parameters that correlate with spasticity severity or with the modulation of the ECS.
Regulation (modulation) of ECS associated with multiple sclerosis and spasticity
9) Confidence 0.03 Published 2009 Journal Neurol. Sci. Section Abstract Doc Link 19768368 Disease Relevance 1.11 Pain Relevance 0.65
Spinal administration of UCM707 did not alter spinal levels of ECs but did significantly inhibit mechanically-evoked responses of neurones in neuropathic, but not sham-operated, rats.
Neg (not) Regulation (alter) of ECs in Spinal associated with endocannabinoid and neuropathic pain
10) Confidence 0.03 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20384778 Disease Relevance 0.61 Pain Relevance 0.70
EMAP-II is a tumor-derived cytokine with potent effects on ECs, including induction of tissue factor, upregulation of TNF receptor 1, and upregulation of E-selectin and P-selectin [94].
Regulation (effects) of ECs associated with cancer and cytokine
11) Confidence 0.01 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.26 Pain Relevance 0.05
However, inflammatory cells may contribute to a state of microvascular hypoperfusion by secreting cytokines and other factors known to affect platelets and ECs.
Regulation (affect) of ECs in platelets associated with inflammation and cytokine
12) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 0.64 Pain Relevance 0.18
Hence, in addition to NO signaling thalidomide appears to affect the migratory pattern of ECs by interfering other signaling pathway/s as well.
Spec (appears) Regulation (affect) of ECs
13) Confidence 0.00 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1456963 Disease Relevance 0.28 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox